Monte Carlo application based on GEANT4 toolkit to simulate a laser-plasma electron beam line for radiobiological studies

Lamia, D.; Russo, G.; Casarino, C.; Gagliano, L.; Candiano, G.C.; Labate, L.; Baffigi, F.; Fulgentini, L.; Giulietti, A.; Koester, P.; Palla, D.; Gizzi, L.A.; Gilardi, M.C.

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment Vol. 786, 113, (2015)

Abstract

We report on the development of a Monte Carlo application, based on the GEANT4 toolkit, for the characterization and optimization of electron beams for clinical applications produced by a laser-driven plasma source. The GEANT4 application is conceived so as to represent in the most general way the physical and geometrical features of a typical laser-driven accelerator. It is designed to provide standard dosimetric figures such as percentage dose depth curves, two-dimensional dose distributions and 3D dose profiles at different positions both inside and outside the interaction chamber. The application was validated by comparing its predictions to experimental measurements carried out on a real laser-driven accelerator. The work is aimed at optimizing the source, by using this novel application, for radiobiological studies and, in perspective, for medical applications.